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Журнал микробиологии, эпидемиологии и иммунобиологии

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РЕКОМБИНАНТНЫЕ АНТИТЕЛА В ПРОТИВОВИРУСНОЙ ТЕРАПИИ: ДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ

https://doi.org/10.36233/0372-9311-2018-6-114-123

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Аннотация

За последние 20 лет было разработано более 60 рекомбинантных моноклональных антител (МкАт) для лечения различных заболеваний. Более 30 препаратов антител разрешены к применению в терапии, включая большую группу препаратов против онкологических заболеваний. Также МкАт используют в трансплантологии, для лечения сердечно-сосудистых, аутоиммунных и, в редких случаях, инфекционных заболеваний. Несмотря на то, что от вирусных заболеваний ежегодно гибнут десятки миллионов людей, в настоящее время разрешен всего один препарат на основе рекомбинантных антител для профилактики РСВ у детей. В обзоре основное внимание уделяется подходам к созданию терапевтических МкАт против вирусных инфекций, примерам терапии вирусных инфекций рекомбинантными антителами и проблемам разработки таких методов лечения.

Об авторах

А. С. Оксанич
НИИ вакцин и сывороток имени И.И.Мечникова
Россия


А. А. Никонова
НИИ вакцин и сывороток имени И.И.Мечникова
Россия


В. В. Зверев
НИИ вакцин и сывороток имени И.И.Мечникова
Россия


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ISSN 0372-9311 (Print)
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