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Журнал микробиологии, эпидемиологии и иммунобиологии. 2018; : 102-109

БАКТЕРИАЛЬНЫЙ МИКРОБИОМ КИШЕЧНИКА ВИЧ-ИНФИЦИРОВАННЫХ ЛЮДЕЙ

Захарова Ю. В.

https://doi.org/10.36233/0372-9311-2018-2-102-109

Аннотация

В обзоре представлены современные данные по состоянию микрофлоры ВИЧ-инфицированных людей и ее участию в прогрессировании заболевания. Описаны механизмы и маркеры бактериальной транслокации через слизистую кишечника в кровоток, их значение для ВИЧ-инфицированных. Исследования кишечного микробиома разных категорий лиц с ВИЧ-статусом демонстрируют противоречивые данные о филогенетическом разнообразии кишечной микрофлоры. Однако в большинстве работ показано, что при ВИЧ-инфекции происходит увеличение в кишечнике представителей рода Prevotella, снижение количественного уровня Bacteroides spp., увеличение удельного веса протеобактерий по отношению к другим представителям кишечной флоры. Показано, что протеобактерии у ВИЧ-инфицированных пациентов являются более метаболически активными, чем у ВИЧ-негативных лиц. Представлены дальнейшие перспективы исследований кишечного микробиома при ВИЧ-инфекции.
Список литературы

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2. Beighton D., Al-Haboubi M., Mantzourani M et al. Oral bifidobacteria : Caries-associated bacteria in older adults. J. Dental Research. 2010, 9 (89): 970-974.

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4. Candela M., Guidotti M., Fabbri A. et al. Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer. Critical Reviews in Microbiology. 2010, 1: 1-14.

5. Cecchinato V., Trindade CJ., Laurens A. et al. Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. Mucosal Immunology. 2008, 1 (4): 279-288.

6. Core C., Munro K., Lay Ch. et al. Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. Journal Allergy Clinical Immunology. 2008, 121: 135-140.

7. Dillona S.M., Daniel N. Franka D.N., Wilsona C.C. The gut microbiome and HIV-pathogenesis: a two-way street. AIDS. 2016, 30: 2737-2751.

8. Dinh D., Volpe G., Duffalo C. et al. Intestinal microbiota, microbial translocation and systemic inflammation in chronic HIV infection. J. Infection Diseases. 2015, 211: 19-27.

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10. Dubourg G. Microbiome of HIV-infected people. Microbial Pathogenesis. 2017, 106: 85-93.

11. Eberhardt K. A., Sarfo F.S., Dompreh A. Helicobacter pylori coinfection is associated with decreased markers of immune activation in ART-naive HIV-positive and in HIV-negative individuals in Ghana. Clinical Infectious Diseases. 2015, 10 (61):1615-1623.

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14. Jenabian M., El-Far M., Vyboh K. et al. Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection. J. Infection Disease. 2015, 3 (212): 355366.

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22. Monaco C.L., Gootenberg D.B., Zhao G. et al. Altered virome and bacterial microbiome in Human immunodeficiency virus-associated acquired immunodeficiency syndrome. Cell Host and Microbe. 2016, 19: 311-322.

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24. Munier A., V.de Lastours, Porcher R. et al. Risk factors for invasive pneumococcal disease in HIV-infected adults in France in the highly active antiretroviral therapy era. International J. Sexually-Transmitted Diseases and AIDS. 2014, 14 (25): 1022-1028.

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28. Preziosi M.J., Kandel S.M., Guiney D.G. et al. Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes ofbacteremia or enteritidis in HIV/AIDS patients in San Diego, California. J. Clinical Microbiology. 2012, 11 (50): 3598-3603.

29. Sandler N.G., Douek D.C. Microbial translocation in HIV infection: causes, consequences and treatment opportunities. Nature Reviews Microbiology. 2012, 9 (10): 655-666.

30. Sinha A., Ma Y., Scherzer R. et al. Association of gut microbiota dependent metabolites and atherosclerosis in HIV. J. American College of Cardiology. 2016, 67 (13): 2240.

31. Stiksrud S., Nowak P., Nwosu F.C. et al. Reduced levels of D-dimer and changes in gut microbiota composition after probiotic intervention in HIV-infected individuals on stable ART. J. Acquired Immune Deficiency Syndromes. 2015, 4 (70): 329-337.

32. Yang., Poles M., Fisch G.S. et al. HIV-induced immunosuppression is associated with colonization of the proximal gut by environmental bacteria. AIDS. 2016, 1 (30): 19-29.

33. Yu G., Fadrosh D., Ma B. et al. Anal microbiota profiles in HIV-positive and HIV-negative MSM. AIDS. 2014, 5 (28): 753-760.

34. Zilberman-Schapira G., Zmora N., Itav N. S. et al. The gut microbiome in human immunodeficiency virus infection. BMC Medicine. 2016, 1 (14): 83.

Journal of microbiology, epidemiology and immunobiology. 2018; : 102-109

GUT BACTERIAL MICROBIOME OF HIV-INFECTED PEOPLE

Zakharova Yu. V.

https://doi.org/10.36233/0372-9311-2018-2-102-109

Abstract

Data on the state of the microflora of HIV-infected people and its participation in the progression of the disease are presented. Mechanisms and markers of bacterial translocation through the intestinal mucosa into the bloodstream, their importance for HIV-infected people are described. Study of intestinal microbiome in different groups of HIV-status people controversial data on the phylogenetic diversity of the intestinal microflora are shown. However, in most studies in HIV-infected increase in the intestine of members of the genus Prevotella, reduction of the quantitative level of Bacteroides spp. increase in the proportion of Proteobacteria compared to the other members of the intestinal flora are noted. It is shown that Proteobacteria in HIV-infected patients are more metabolically active than HIV-negative individuals. Further studies of the intestinal microbiome in HIV-infection are presented.
References

1. Araujo-Perez F., McCoy AN., Okechukwu C et al. Differences in microbial signatures between rectal mucosal biopsies and rectal swabs. Gut Microbes. 2012, 3 (6): 530-535.

2. Beighton D., Al-Haboubi M., Mantzourani M et al. Oral bifidobacteria : Caries-associated bacteria in older adults. J. Dental Research. 2010, 9 (89): 970-974.

3. Burgener A., McGowan I., Klatt N.R. HIV and mucosal barrier interactions: consequences for transmission and pathogenesis. Current Opinion in Immunology. 2015, 36: 22-30.

4. Candela M., Guidotti M., Fabbri A. et al. Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer. Critical Reviews in Microbiology. 2010, 1: 1-14.

5. Cecchinato V., Trindade CJ., Laurens A. et al. Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques. Mucosal Immunology. 2008, 1 (4): 279-288.

6. Core C., Munro K., Lay Ch. et al. Bifidobacterium pseudocatenulatum is associated with atopic eczema: a nested case-control study investigating the fecal microbiota of infants. Journal Allergy Clinical Immunology. 2008, 121: 135-140.

7. Dillona S.M., Daniel N. Franka D.N., Wilsona C.C. The gut microbiome and HIV-pathogenesis: a two-way street. AIDS. 2016, 30: 2737-2751.

8. Dinh D., Volpe G., Duffalo C. et al. Intestinal microbiota, microbial translocation and systemic inflammation in chronic HIV infection. J. Infection Diseases. 2015, 211: 19-27.

9. Dubourg G. Impact of HIV on the human gut microbiota: challenges and perspectives. Human Microbiome J. 2016, 2: 3-9.

10. Dubourg G. Microbiome of HIV-infected people. Microbial Pathogenesis. 2017, 106: 85-93.

11. Eberhardt K. A., Sarfo F.S., Dompreh A. Helicobacter pylori coinfection is associated with decreased markers of immune activation in ART-naive HIV-positive and in HIV-negative individuals in Ghana. Clinical Infectious Diseases. 2015, 10 (61):1615-1623.

12. Goedert. J.J. Effects of HIV, immune deficiency, and confounding on the distal gut microbiota. EBioMedicine. 2016, 5: 14-15.

13. Hensley-McBain T., Zevin A., Manuzak J. et al. Effects of fecal microbial transplantation on microbiome and immunity in simian immunodeficiency virus-infected macaques. J. Virology. 2016, 10 (90): 4981-4989.

14. Jenabian M., El-Far M., Vyboh K. et al. Immunosuppressive tryptophan catabolism and gut mucosal dysfunction following early HIV infection. J. Infection Disease. 2015, 3 (212): 355366.

15. Kutikhin A.G., Yuzhalin A.E., Brusina E.B. Infectious agents and cancer. Germany: Springer, 2013.

16. Littman D.R., Rudensky AY. Th17 and regulatory T cells in mediating and restraining inflammation. Cell. 2010, 6 (140): 845-858.

17. Lozupone C.A., Li M., Campbell T.B. et al. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host and Microbe. 2013, 14: 329-339.

18. Lozupone C. A., Rhodes M., Neff C. et al. HIV-induced alteration in gut microbiota: driving factors, consequences and effects of antiretroviral therapy. Gut Microbes. 2014, 4 (5): 562570.

19. Ma W., Zhang L., Zeng P. et al. An analysis of human microbe-disease associations. Briefings in Bioinformatics. 2017, 18 (1): 85-97.

20. Manner I., Baekken M., Klave D. et al. Markers of microbial translocation predict hypertension in HIV-infected individuals. HIV Medicine. 2013, 6 (14): 354-361.

21. McHardy I.H., Li X., Tong M. et al. HIV infection is associated with compositional and functional shifts in the rectal mucosal microbiota. Microbiome. 2013, 1 (1): 26.

22. Monaco C.L., Gootenberg D.B., Zhao G. et al. Altered virome and bacterial microbiome in Human immunodeficiency virus-associated acquired immunodeficiency syndrome. Cell Host and Microbe. 2016, 19: 311-322.

23. Mudd J.C., Brenchley J.M. Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression. J. Infectious Diseases. 2016, 214 (suppl 2): 58-66.

24. Munier A., V.de Lastours, Porcher R. et al. Risk factors for invasive pneumococcal disease in HIV-infected adults in France in the highly active antiretroviral therapy era. International J. Sexually-Transmitted Diseases and AIDS. 2014, 14 (25): 1022-1028.

25. Noguera-Julian M., Rocafort M., Guillen Y et al. Gut microbiota linked to sexual preference and HIV infection. EBioMedcine. 2016, 5:135-146.

26. Nowak P., Troseid M., Avershina E. et al. Gut microbiota diversity predicts immune status in HIV-1 infection. AIDS. 2015, 18 (29): 2409-2418.

27. Perez-Santiago J., Gianella S., Massanella M. et al. Gut.actobacillales are associated with higher CD4 and less microbial translocation during HIV infection. AIDS. 2013, 12 (27): 19211931.

28. Preziosi M.J., Kandel S.M., Guiney D.G. et al. Microbiological analysis of nontyphoidal Salmonella strains causing distinct syndromes ofbacteremia or enteritidis in HIV/AIDS patients in San Diego, California. J. Clinical Microbiology. 2012, 11 (50): 3598-3603.

29. Sandler N.G., Douek D.C. Microbial translocation in HIV infection: causes, consequences and treatment opportunities. Nature Reviews Microbiology. 2012, 9 (10): 655-666.

30. Sinha A., Ma Y., Scherzer R. et al. Association of gut microbiota dependent metabolites and atherosclerosis in HIV. J. American College of Cardiology. 2016, 67 (13): 2240.

31. Stiksrud S., Nowak P., Nwosu F.C. et al. Reduced levels of D-dimer and changes in gut microbiota composition after probiotic intervention in HIV-infected individuals on stable ART. J. Acquired Immune Deficiency Syndromes. 2015, 4 (70): 329-337.

32. Yang., Poles M., Fisch G.S. et al. HIV-induced immunosuppression is associated with colonization of the proximal gut by environmental bacteria. AIDS. 2016, 1 (30): 19-29.

33. Yu G., Fadrosh D., Ma B. et al. Anal microbiota profiles in HIV-positive and HIV-negative MSM. AIDS. 2014, 5 (28): 753-760.

34. Zilberman-Schapira G., Zmora N., Itav N. S. et al. The gut microbiome in human immunodeficiency virus infection. BMC Medicine. 2016, 1 (14): 83.