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Журнал микробиологии, эпидемиологии и иммунобиологии. 2017; : 65-71

ГОРИЗОНТАЛЬНАЯ ТРАНСМИССИЯ ВАКЦИННОГО ШТАММА ВИРУСА ПАРОТИТА ОТ ВАКЦИНИРОВАННЫХ ИХ БЛИЗКИМ КОНТАКТАМ

Отрашевская Е. В., Кулак М. В., Букин Е. К., Горбунов М. А., Игнатьев Г. М.

https://doi.org/10.36233/0372-9311-2017-3-65-71

Аннотация

Цель. С целью изучения горизонтальной трансмиссии вакцинного штамма вируса паротита (ВП) было проведено контролируемое исследование. Материалы и методы. В исследовании приняли участие 20 супружеских пар. В течение 42 дней после однократной вакцинации одного из супругов проводили мониторинг состояния обоих супругов, изучали в динамике уровень специфических IgM и JgG в сыворотке крови, и вируснейтрализующих IgG в сыворотке крови и слюне, также определяли РНК ВП в образцах крови и слюны. Амплифицированные фрагменты генов F, SH, NP и HN ВП были секвенированы. Результаты. Передача вакцинного штамма ВП была зарегистрирована во всех супружеских парах, кроме одной. За исключением одного контактного супруга, все остальные продемонстрировали формирование специфического иммунного ответа. На 4 месяце наблюдения группа вакцинированных супругов статистически достоверно отличалась от группы контактных супругов только по показателям общего содержания специфических IgG и их авидности. Заключение. Таким образом, в нашем исследовании продемонстрирована горизонтальная трансмиссия штамма ВП в супружеских парах после вакцинации одного из супругов, которая привела к формированию специфического иммунитета у 95% контактных лиц.
Список литературы

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10. Measles, mumps, and rubella vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: Recommendations of the advisory committee on immunization practices (ACIP). MMWR. CDC. 1998, 47: RR-8.

11. Morfin E, Beguin A., Una B., Thouvenot D. Detection of measles vaccine in the throat of a vaccinated child. Vaccine. 2002, 20 (11-12): 1541-1543.

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13. Narita M., Matsuzono Y., Takekoshi Y. et al. Analysis of mumps vaccine failure by means of avidity testing for mumps virus-specific immunonoglobulin G. Clin. Diagn. Lab. Immunol. 1998, 5: 799-803.

14. Said M.A., Haile C., Palabindala V. et al. Transmission of vaccinia virus, possibly through sexual contact, to a woman at high risk for adverse complications. Mil. Med. 2013, Dec; 178 (12): e 1375-1378. doi: 10.7205/MILMED-D-13-00233.

15. Salzman M. B., Sharrar R. G., Steinberg S., LaRussa R Transmission of varicella-vaccine virus from a healthy 12-month-old child to his pregnant mother. J. Pediatr. 1997, 131: 151-154.

16. Sawada H., Yano S., Oka Y., Togashi T. Transmission of Urabe mumps vaccine between siblings. Lancet. 1993, 342 (8867): 371.

17. Tesovic G., Poljak M., Kocjan B.J. et al. Horizontal transmission of the Leningrad-Zagreb mumps vaccine strain: a report of three cases. Vaccine. 2008, 26 (16): 1922-1925.

18. Vukic B.T., Pavic I., Milotic I., Slavuljica I. Aseptic meningitis after transmission of the Leningrad-Zagreb mumps vaccine from vaccinee to susceptible contact. Vaccine. 2008, 26 (38): 4879.

Journal of microbiology, epidemiology and immunobiology. 2017; : 65-71

HORIZONTAL TRANSMISSION OF PAROTITIS VACCINE STRAIN FROM VACCINATED TO CLOSE CONTACTS

Otrashevskaya E. V., Kulak M. V., Bukin E. K., Gorbunov M. A., Ignatyev G. M.

https://doi.org/10.36233/0372-9311-2017-3-65-71

Abstract

Aim. A controlled study was carried out regarding horizontal transmission of the vaccine strain of parotitic virus (PV). Materials and methods. 20 couples took part in the study. Monitoring of both spouses was carried out for 42 days after a single vaccination of one of them, levels of specific IgM and IgG in sera and virus-neutralizing IgG in sera and saliva were studied in dynamics, PV RNA was also determined in sera and saliva samples. Amplified fragments of F, SH, NP and HN genes of PV were sequenced. Results. Transfer of PV vaccine strain was registered in all the couples except for one. Except a single contact spouse, all the rest demonstrated formation of a specific immune response. At month 4 of the observation, group of vaccinated spouses differed significantly from a group of contact spouses only by total content of specific IgG and their avidity. Conclusion. Horizontal transmission of PV strain was demonstrated in couples after vaccination of one of the spouses and resulted in formation of specific immunity in 95% of contact individuals.
References

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3. Amexis G., Fineschi N., Chumakov K. Correlation of genetic variability with safety of mumps vaccine Urabe AM9 strain. Virology. 2001, 287 (1): 234-241.

4. Atrasheuskaya A., Kulak M., Fisenko E.G. et al. Horizontal transmission of the Leningrad-Zagreb mumps vaccine strain: a report of six symptomatic cases of parotitis and one case of meningitis. Vaccine. 2012, 30 (36): 5324-5326.

5. Atrasheuskaya A.V., Neverov A.A., Rubin S., Ignatyev G.M. Horizontal transmission of the Leningrad-3 live attenuated mumps vaccine virus. Vaccine. 2006, 24: 1530-1536.

6. Brunell Ph-A., Argaw T. Chickenpox attributable to a vaccine virus contracted from a vaccinee with zoster. Pediatrics. 2000, 106: 28.

7. Huang X., Cao Y., Tan S. Horizontal transmission of live attenuated hepatitis A vaccine vims. Zhonghua Yi Xue Zhi. 2001, 8: 465-467.

8. Kaic B., Gjenero-Margan I., Aleraj B. et al. Transmission of the L-Zagreb mumps vaccine vims, Croatia 2005-2008. Euro Surveillance. 2008, 13: 496.

9. Kaic B., Gjenero-Margan I., Aleraj B. et al. Spotlight on measles 2010: excretion of vaccine strain measles vims in urine and pharyngeal secretions of a child with vaccine associated febrile rash illness, Croatia, 2010. Euro Surveill. 2010, 15 (35): 1-2.

10. Measles, mumps, and rubella vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: Recommendations of the advisory committee on immunization practices (ACIP). MMWR. CDC. 1998, 47: RR-8.

11. Morfin E, Beguin A., Una B., Thouvenot D. Detection of measles vaccine in the throat of a vaccinated child. Vaccine. 2002, 20 (11-12): 1541-1543.

12. Nagai T, Nakayama T. Mumps vaccine virus genome is present in throat swabs obtained from uncomplicated healthy recipients. Vaccine. 2001, 19: 1353-1355.

13. Narita M., Matsuzono Y., Takekoshi Y. et al. Analysis of mumps vaccine failure by means of avidity testing for mumps virus-specific immunonoglobulin G. Clin. Diagn. Lab. Immunol. 1998, 5: 799-803.

14. Said M.A., Haile C., Palabindala V. et al. Transmission of vaccinia virus, possibly through sexual contact, to a woman at high risk for adverse complications. Mil. Med. 2013, Dec; 178 (12): e 1375-1378. doi: 10.7205/MILMED-D-13-00233.

15. Salzman M. B., Sharrar R. G., Steinberg S., LaRussa R Transmission of varicella-vaccine virus from a healthy 12-month-old child to his pregnant mother. J. Pediatr. 1997, 131: 151-154.

16. Sawada H., Yano S., Oka Y., Togashi T. Transmission of Urabe mumps vaccine between siblings. Lancet. 1993, 342 (8867): 371.

17. Tesovic G., Poljak M., Kocjan B.J. et al. Horizontal transmission of the Leningrad-Zagreb mumps vaccine strain: a report of three cases. Vaccine. 2008, 26 (16): 1922-1925.

18. Vukic B.T., Pavic I., Milotic I., Slavuljica I. Aseptic meningitis after transmission of the Leningrad-Zagreb mumps vaccine from vaccinee to susceptible contact. Vaccine. 2008, 26 (38): 4879.